ChemDiverse now shipping!

Chemical Design is pleased to announce that the initial release of the
exciting ChemDiverse Module for Combinatorial Chemistry is now shipping.
Development of these powerful and innovative tools for drug discovery was
steered by the Combinatorial Chemistry Special Interest Group, established
earlier this year by Chemical Design in conjunction with a number of
leading pharmaceutical and agrochemical organizations. Contributions from
group members ensure that ChemDiverse meets the requirements of today's
industry for reduced discovery timescales and costs, while continuing to
explore vast numbers of diverse molecules for new lead compounds.

Significant requirements from a number of major pharmaceutical
organizations, including Glaxo, Organon and Rhone-Poulenc Rorer, have
become key features of ChemDiverse. Glaxo identified the need to locate
suitable reagents for combinatoral chemistry library generation from
suppliers' catalogs held in database format, and to load the corresponding
R-groups into a component database for library registration and expansion.
Organon wanted to compare databases, based on the similarity of the
pharmacophores exhibited by each, to indicate whether a new database would
be likely to yield as yet unexplored pharmacophores. Rhone-Poulenc Rorer
made suggestions concerning the types and geometry definitions of
pharmacophores used in ChemDiverse's pharmacophore identification. All
these requirements are now met in ChemDiverse with novel reagent
searching, library diversity analysis and design, and enhanced
pharmacophore identification capabilities.

The combinatorial chemistry approach to diversity results in the generation
of libraries or databases of new molecules, created by combining basic
molecular fragments. ChemDiverse is an exciting computational solution to
library generation and analysis, using pioneering database registration
and expansion, library design, and pharmacophore identification for
mixtures of active molecules. Molecular libraries are created using a
generic Markush representation with central core components and attached
R-groups. Lists of alternative R-groups are specified interactively, or by
substructure or reagent searching.

ChemDiverse is the latest additional module for Chem-X, Chemical Design's
innovative discovery software. Chem-X is currently used by over 700
research sites world-wide including divisions of most major multi-national
pharmaceutical organizations. The software is best known for its 3D
database searching where Chemical Design has demonstrated technology two
years ahead of the competition. Its advanced capabilities are proven for
success, yielding new patentable drugs now in development.

For further information call Chemical Design at (201) 529-3323, or fax us
at (201) 529-2443.

Chemical Design Inc
200 Route 17 South, Suite 120
Mahwah, NJ 07430
 
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