$Unique_ID{BRK01878}
$Pretitle{}
$Title{CHLORDIAZEPOXIDE AND CLIDINIUM COMBINATION}
$Subject{Clindex (Rugby)
Clinoxide (Geneva Generics)
Clipoxide (Schein)
Librax (Roche)
Lidox (Major)
Zebrax (Hauck)}
$Volume{}
$Log{
Librax*0187801.scf}

Copyright (C) 1991 Publications International, Ltd.


CHLORDIAZEPOXIDE AND CLIDINIUM COMBINATION
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BRAND NAMES (Manufacturers):
     Clindex (Rugby)
     Clinoxide (Geneva Generics)
     Clipoxide (Schein)
     Librax (Roche)
     Lidox (Major)
     Zebrax (Hauck)
TYPE OF DRUG:
     Benzodiazepine antianxiety and anticholinergic
INGREDIENTS:
     Chlordiazepoxide and clidinium
DOSAGE FORM:
     Capsules (5 mg chlordiazepoxide and 2.5 mg clidinium)
STORAGE:
     Chlordiazepoxide and clidinium combination capsules should be stored at
       room temperature in a tightly closed, light-resistant container.

USES

     Chlordiazepoxide and clidinium combination is used in conjunction with
other drugs to treat peptic ulcer or irritable bowel syndrome.  Clidinium is
an anticholinergic agent that slows the activity of the gastrointestinal tract
and reduces the production of stomach acid.  Chlordiazepoxide belongs to a
group of drugs known as benzodiazepine tranquilizers.  It is not clear exactly
how chlordiazepoxide works, but it may relieve anxiety by acting as a
depressant of the central nervous system (brain and spinal cord).

TREATMENT

     You should take chlordiazepoxide and clidinium combination 30 to 60
minutes before meals.  It can be taken with water or milk.  Do not take it
with antacids, since they may interfere with its absorption.
     If you miss a dose, take the missed dose as soon as possible, unless it
is almost time for your next dose.  In that case, do not take the missed dose
at all; just return to your regular dosing schedule.  Do not double the next
dose.

SIDE EFFECTS

     Minor.

     Blurred vision, change in your sense of taste, confusion, constipation,
decreased sweating, depression, diarrhea, dizziness, drowsiness, dry mouth,
fatigue, headache, insomnia, nausea, or vomiting.  These side effects should
disappear as your body adjusts to the medication.
     This medication can cause increased sensitivity to sunlight.  You should,
therefore, avoid prolonged exposure to sunlight and sunlamps.  Wear protective
clothing and sunglasses, and use an effective sunscreen.
     Dry mouth can be relieved by chewing sugarless gum or by sucking on ice
chips or a piece of hard candy.
     To relieve constipation, increase the amount of fiber in your diet (fresh
fruits and vegetables, salads, bran, and whole-grain breads), exercise, and
drink more water (unless your doctor directs you to do otherwise).
     To avoid dizziness or light-headedness when you stand, contract and relax
the muscles of your legs for a few minutes before rising.  Do this by pushing
one foot against the floor while raising the other foot slightly, alternating
feet so that you are "pumping" your legs in a pedaling motion.

     Major.

     Tell your doctor about any side effects that are persistent or
particularly bothersome.  IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about
decreased sexual ability, difficulty in breathing, difficult or painful
urination, excitation, fluid retention, hallucinations, palpitations, rash,
sore throat, uncoordinated movements, or yellowing of the eyes or skin.

INTERACTIONS

     This medication interacts with several other types of drugs:
     1. Extreme drowsiness can occur when this medicine is taken with other
central nervous system depressants (such as alcohol, antihistamines,
barbiturates, muscle relaxants, narcotics, pain medications, phenothiazine
tranquilizers, and sleeping medications) or with tricyclic antidepressants.
     2. Chlordiazepoxide can decrease the effectiveness of carbamazepine,
levodopa, and oral anticoagulants (blood thinners) and may increase the
effects of phenytoin.
     3. Disulfiram, oral contraceptives (birth control pills), isoniazid, and
cimetidine can increase the blood levels of chlordiazepoxide, which could
possibly lead to toxic effects.
     4. Concurrent use of rifampin may decrease the effectiveness of
chlordiazepoxide and clidinium.
     5. Amantadine, haloperidol, phenothiazine tranquilizers, procainamide,
quinidine, and tricyclic antidepressants may increase the side effects of
clidinium.
     Before starting to take this medication, BE SURE TO TELL YOUR DOCTOR
about any medications you are currently taking, especially any of those listed
above.

WARNINGS

     * Tell your doctor if you have ever had unusual or allergic reactions to
any medications, especially to chlordiazepoxide or other benzodiazepine
tranquilizers (such as alprazolam, clorazepate, diazepam, flurazepam,
halazepam, lorazepam, oxazepam, prazepam, temazepam, and triazolam) or to
clidinium.
     * Tell your doctor if you now have or if you have ever had glaucoma,
obstructed bladder or intestine, enlarged prostate gland, heart disease, lung
disease, liver disease, kidney disease, ulcerative colitis, porphyria, high
blood pressure, myasthenia gravis, epilepsy, thyroid disease, emotional
instability, or hiatal hernia.
     * This medication can decrease sweating and heat release from the body.
You should, therefore, avoid becoming overheated by strenuous exercise in hot
weather and should avoid taking hot baths, showers, and saunas.
     * This medicine can cause drowsiness.  Avoid tasks that require
alertness, such as driving a car or operating potentially dangerous equipment.
     * Before having surgery or any other medical or dental treatment, tell
your doctor or dentist that you are taking this drug.
     * This medication has the potential for abuse and must be used with
caution.  Tolerance develops quickly; do not increase the dosage unless you
first consult your doctor.  It is also important not to stop taking this drug
suddenly if you have been using it in large amounts or for longer than several
weeks.  Your doctor may reduce the dosage gradually.
     * This is a safe drug when used properly.  When it is combined with other
sedative drugs or alcohol, however, serious side effects may develop.
     * Be sure to tell your doctor if you are pregnant.  This medicine may
increase the chance of birth defects if it is taken during the first three
months of pregnancy.  In addition, too much use of this medicine during the
last six months of pregnancy may cause the baby to become dependent on it.
This may result in withdrawal symptoms in the infant at birth.  Use of this
medicine during the last weeks of pregnancy may cause excessive drowsiness,
slowed heartbeat, and breathing difficulties in the newborn infant.  Also,
tell your doctor if you are breast-feeding an infant.  This medicine may pass
into breast milk and cause excessive drowsiness, slowed heartbeat, and
breathing difficulties in the nursing infant.

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The material contained here is "FOR INFORMATION ONLY" and should not replace 
the counsel and advice of your personal physician.  Promptly consulting your 
doctor is the best path to a quick and successful resolution of any medical 
problem.
