$Unique_ID{BRK01840}
$Pretitle{}
$Title{ATROPINE, SCOPOLAMINE, HYOSCYAMINE, AND PHENOBARBITAL COMBINATION}
$Subject{Barophen (various manufacturers)
belladonna alkaloids with phenobarbital (various manufacturers)
Donnamor (H.L. Moore)
Donna-Sed (Vortech)
Donnatal (Robins)
Hyosophen (Rugby)
Kinesed (Stuart)
Malatal (Mallard)
Neoquess (Forest)
Relaxadon (Geneva Generics)
Spasmolin (various manufacturers)
Spasmophen (Lannett)
Spasquid (Geneva Generics)
Susano (Halsey)}
$Volume{}
$Log{}

Copyright (C) 1991 Publications International, Ltd.


ATROPINE, SCOPOLAMINE, HYOSCYAMINE, AND PHENOBARBITAL COMBINATION
------------------------------------------------------------------------------

BRAND NAMES (Manufacturers):
     Barophen (various manufacturers)
     belladonna alkaloids with phenobarbital (various manufacturers)
     Donnamor (H.L. Moore)
     Donna-Sed (Vortech)
     Donnatal (Robins)
     Hyosophen (Rugby)
     Kinesed (Stuart)
     Malatal (Mallard)
     Neoquess (Forest)
     Relaxadon (Geneva Generics)
     Spasmolin (various manufacturers)
     Spasmophen (Lannett)
     Spasquid (Geneva Generics)
     Susano (Halsey)
TYPE OF DRUG:
     Anticholinergic and sedative
INGREDIENT:
     Satropine, scopolamine, hyoscyamine, and phenobarbital
DOSAGE FORMS:
     Tablets (0.0194 mg atropine, 0.0065 mg scopolamine, 0.1037 mg
       hyoscyamine, and 16.2 mg phenobarbital)
     Capsules (0.0194 mg atropine, 0.0065 mg scopolamine, 0.1037 mg
       hyoscyamine, and 16.2 mg phenobarbital)
     Oral elixir (0.0194 mg atropine, 0.0065 mg scopolamine, 0.1037 mg
       hyoscyamine, and 16.2 mg phenobarbital, with 23% alcohol)
STORAGE:
     The medication should be stored at room temperature (never frozen) in a
       tightly closed, light-resistant container.

USES

     This medication is used to treat bed-wetting, lack of bladder control,
motion sickness, premenstrual tension, and stomach and intestinal disorders.
     Atropine, scopolamine, and hyoscyamine belong to a group of drugs known
as belladonna alkaloids or anticholinergic agents.  These drugs block certain
nerve pathways, thereby slowing the gastrointestinal tract and decreasing
urination.  Phenobarbital is a sedative that acts directly on the brain to
slow the activity of the nervous system.

TREATMENT

     This medication should be taken 30 minutes to one hour before meals
(unless your doctor directs you to do otherwise).  In order to reduce stomach
upset, you can take it with food or with a glass of water or milk.
     At least one hour should separate doses of this drug and either antacids
or antidiarrheal medications--they may prevent gastrointestinal absorption of
this drug.
     Measure the liquid form of this medication carefully with a specially
designed 5-ml measuring spoon.  An ordinary kitchen teaspoon is not accurate
enough.
     If you miss a dose, don't take the missed dose at all; just return to
your regular dosing schedule.  Don't double the next dose.

SIDE EFFECTS

     Minor.

     Confusion; constipation; decreased sexual desire; dizziness; drowsiness;
dry mouth, nose, and throat; headache; insomnia; loss of taste; muscle pain;
nausea; nervousness; reduced sweating; sensitivity of eyes to sunlight;
vomiting; or weakness.  These side effects should disappear as your body
adjusts to the medication.
     If you are constipated, increase the amount of fiber in your diet (fresh
fruits and vegetables, salads, bran, and whole-grain breads), exercise, and
drink more water (unless your doctor directs you to do otherwise).
     Chew sugarless gum or suck on ice chips or a piece of hard candy to
reduce mouth dryness.
     Wear sunglasses if your eyes become sensitive to light.
     To avoid dizziness or light-headedness when you stand, contract and relax
the muscles of your legs for a few moments before rising.  Do this by pushing
one foot against the floor while raising the other foot slightly, alternating
feet so that you are "pumping" your legs in a pedaling motion.

     Major.

     Tell your doctor about any side effects that are persistent or
particularly bothersome.  IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about
blurred vision, difficulty in breathing, difficulty in urinating,
hallucinations, hot and dry skin, palpitations, rash, slurred speech, sore
throat, or yellowing of the eyes or skin.

INTERACTIONS

     This medication interacts with several other types of drugs:
     1. The belladonna alkaloids and phenobarbital can cause extreme
drowsiness when combined with central nervous system depressants (such as
alcohol, antihistamines, barbiturates, benzodiazepine tranquilizers, muscle
relaxants, narcotics, and pain medications) or with tricyclic antidepressants.
     2. Amantadine, antihistamines, haloperidol, monoamine oxidase (MAO)
inhibitors, phenothiazine tranquilizers, procainamide, quinidine, and
tricyclic antidepressants can increase the side effects of the belladonna
alkaloids.  At least 14 days should separate the use of this drug and the use
of an MAO inhibitor.
     3. Phenobarbital can increase the elimination and decrease the
effectiveness of oral anticoagulants (blood thinners, such as warfarin),
cortisone-like medications, digoxin, griseofulvin, doxycycline, metronidazole,
phenytoin, and tricyclic antidepressants.

WARNINGS

     * Tell your doctor about unusual or allergic reactions you have had to
any medications, especially to atropine, scopolamine, hyoscyamine,
phenobarbital, or to other barbiturates (such as butalbital, primidone,
pentobarbital, and secobarbital).
     * Tell your doctor if you now have or if you have ever had glaucoma,
heart disease, hiatal hernia, high blood pressure, internal bleeding, kidney
disease, liver disease, lung disease, myasthenia gravis, porphyria, enlarged
prostate gland, obstructed bladder, obstructed intestine, ulcerative colitis,
or thyroid disease.
     * If this medication makes you dizzy or drowsy or blurs your vision, do
not take part in any activity that requires alertness, such as driving a car
or operating potentially dangerous equipment.  Be careful on stairs, and avoid
getting up from a lying or sitting position suddenly.
     * This medication can decrease sweating and heat release from the body.
Therefore, avoid getting overheated by strenuous exercise in hot weather, and
avoid taking hot baths, showers, and saunas.  Before having surgery or any
other medical or dental treatment, tell the doctor or dentist that you are
taking this drug.
     * Be sure to tell your doctor if you are pregnant.  This medication
crosses the placenta.  Phenobarbital given to the mother close to term can
cause breathing problems and bleeding complications in the newborn infant.
Also, tell your doctor if you are breast-feeding an infant.  Small amounts of
this medication pass into breast milk and may cause excessive drowsiness or
irritability in the nursing infant.

----------------

The material contained here is "FOR INFORMATION ONLY" and should not replace 
the counsel and advice of your personal physician.  Promptly consulting your 
doctor is the best path to a quick and successful resolution of any medical 
problem.
