$Unique_ID{BRK01832}
$Pretitle{}
$Title{ASPIRIN AND OXYCODONE COMBINATION}
$Subject{Codoxy (Halsey)
oxycodone hydrochloride, oxycodone terephthalate, and aspirin (various
manufacturers)
Percodan (DuPont)
Percodan-Demi (DuPont)}
$Volume{}
$Log{
Percodan*0183201.scf}

Copyright (C) 1991 Publications International, Ltd.


ASPIRIN AND OXYCODONE COMBINATION
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BRAND NAMES (Manufacturers):
     Codoxy (Halsey)
     oxycodone hydrochloride, oxycodone terephthalate, and aspirin (various
       manufacturers)
     Percodan (DuPont)
     Percodan-Demi (DuPont)
TYPE OF DRUG:
     Analgesic combination
INGREDIENT:
     Saspirin and oxycodone
DOSAGE FORM:
     Tablets (325 mg aspirin with 2.25 mg oxycodone hydrochloride and 0.19 mg
       oxycodone terephthalate; 325 mg aspirin with 4.5 mg oxycodone
       hydrochloride and 0.38 mg oxycodone terephthalate)
STORAGE:
     Store at room temperature in a tightly closed container.  Moisture causes
       the aspirin in this product to decompose.

USES

     This combination medication is used to relieve moderate to severe pain.
Oxycodone is a narcotic analgesic that acts on the central nervous system to
relieve pain.

TREATMENT

     In order to avoid stomach upset, you can take this medication with food
or milk.
     This medication works most effectively if you take it at the onset of
pain, rather than waiting until the pain becomes intense.
     If you are taking this medication on a regular schedule and you miss a
dose, take the missed dose as soon as possible, unless it is almost time for
your next dose.  In that case, don't take the missed dose at all; just return
to your regular dosing schedule.  Do not double the next dose.

SIDE EFFECTS

     Minor.

     Constipation, dizziness, drowsiness, dry mouth, false sense of
well-being, flushing, indigestion, light-headedness, loss of appetite, nausea,
sweating, or vomiting.  These side effects should disappear as your body
adjusts to the medication.
     If you are constipated, increase the amount of fiber in your diet (fresh
fruits and vegetables, salads, bran, and whole-grain breads), drink more
water, and exercise (unless your doctor directs you to do otherwise).
     Chew sugarless gum or suck on ice chips or a piece of hard candy to
reduce mouth dryness.
     If you feel dizzy, light-headed, or nauseated, sit or lie down for a
while; get up from a sitting or lying position slowly, and be careful on
stairs.

     Major.

     Tell your doctor about any side effects that are persistent or
particularly bothersome.  IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about
bloody or black, tarry stools; chest tightness; difficult or painful
urination; difficulty in breathing; fatigue; itching; palpitations; rash;
ringing in the ears; severe abdominal pain; tremors; or yellowing of the eyes
or skin.

INTERACTIONS

     This medication interacts with several other types of drugs:
     1. Concurrent use of this medication with other central nervous system
depressants (such as alcohol, antihistamines, barbiturates, benzodiazepine
tranquilizers, muscle relaxants, and phenothiazine tranquilizers) or with
tricyclic antidepressants can cause extreme drowsiness.
     2. The concurrent use of aspirin and oxycodone combination and monoamine
oxidase (MAO) inhibitors should be avoided.  At least 14 days should separate
the use of this drug and the use of an MAO inhibitor.
     3. Alcohol and anti-inflammatory medications can increase the
gastrointestinal side effects of this medication.
     4. The side effects of anticoagulants (blood thinners, such as warfarin),
oral antidiabetic agents, phenytoin, and methotrexate may be increased by the
aspirin in this product.
     5. Large doses of antacids increase the elimination of the aspirin
portion of this medication from the body and decrease its effectiveness.
     6. The aspirin portion of this medication may decrease the antigout
effects of probenecid and sulfinpyrazone.
     BE SURE TO TELL YOUR DOCTOR about any medications you are currently
taking, especially any listed above.

WARNINGS

     * Tell your doctor about unusual or allergic reactions you have had to
medications, especially to aspirin, methyl salicylate (oil of wintergreen),
diclofenac, diflunisal, flurbiprofen, fenoprofen, ibuprofen, indomethacin,
ketoprofen, meclofenamate, mefenamic acid, naproxen, piroxicam, sulindac, or
tolmetin or to oxycodone or other narcotic analgesics (such as codeine,
hydrocodone, hydromorphone, meperidine, methadone, morphine, or propoxyphene).
     * Tell your doctor if you now have or if you have ever had abdominal
disease, Addison's disease, bleeding or blood disorders, brain disease,
colitis, epilepsy, gallstones or gallbladder disease, head injuries, heart
disease, hemophilia, kidney disease, liver disease, lung disease, peptic
ulcers, porphyria, enlarged prostate gland, or thyroid disease.
     * If this drug makes you dizzy or drowsy, do not take part in any
activity that requires alertness, such as driving a car or operating
potentially dangerous equipment.
     * Before having surgery or any other medical or dental treatment, tell
your doctor or dentist that you are taking this drug.  Aspirin-containing
medications are usually stopped five to seven days before surgery, in order to
prevent complications.
     * The use of aspirin in children (about 16 years of age or less) with the
flu or chicken pox has been associated with a rare, life-threatening condition
called Reye's syndrome.  Aspirin-containing products should, therefore, not be
given to children who have any signs of infection.
     * Because this drug contains oxycodone, it has the potential for abuse
and must be used with caution.  Usually, it should not be taken on a regular
schedule for longer than ten days at a time.  Tolerance develops quickly; do
not increase the dosage or stop taking the drug abruptly, unless you first
consult your doctor.  If you have been taking large amounts of this medication
for long periods, you may experience a withdrawal reaction (muscle aches,
diarrhea, gooseflesh, runny nose, nausea, vomiting, shivering, trembling,
stomach cramps, sleep disorders, irritability, weakness, excessive yawning, or
sweating).  Your doctor may, therefore, want to reduce the dosage gradually to
prevent or minimize this response.
     * Because this product contains aspirin, additional medications that
contain aspirin should not be taken without your doctor's approval.  Check the
labels on over-the-counter (nonprescription) pain, sinus, allergy, asthma,
cough, and cold products to see if they contain aspirin.
     * Diabetic patients should be aware that large doses of aspirin (more
than eight 325-mg tablets per day) may interfere with urine sugar testing.
Diabetics should, therefore, check with their doctor before changing their
insulin dose.
     * Be sure to tell your doctor if you are pregnant.  The effects of this
medication during pregnancy have not been thoroughly studied in humans.
Oxycodone, used regularly in large doses during pregnancy, may result in
addiction of the fetus, leading to withdrawal symptoms (irritability,
excessive crying, tremors, fever, vomiting, diarrhea, sneezing, or excessive
yawning) at birth.  Large amounts of aspirin taken close to the end of
pregnancy may prolong labor and cause bleeding problems in the mother and
heart problems in the newborn infant.  Also, tell your doctor if you are
breast-feeding an infant.  Small amounts of this medication may pass into
breast milk and cause excessive drowsiness in the nursing infant.

----------------

The material contained here is "FOR INFORMATION ONLY" and should not replace 
the counsel and advice of your personal physician.  Promptly consulting your 
doctor is the best path to a quick and successful resolution of any medical 
problem.
