$Unique_ID{BRK00462}
$Pretitle{Ill Defined Symptoms and Rare Diseases}
$Title{Information on "Progressive Supranuclear Palsy"}
$Subject{palsy brain supranuclear}
$Volume{N-1}
$Log{}

Copyright (c) 1991   Tribune Media Services, Inc.


Information on "Progressive Supranuclear Palsy"


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QUESTION:  My father-in-law has been diagnosed as having "progressive
supranuclear palsy"--a very frustrating and heart wrecking disease to watch
happen to a once healthy and virile man.  Although family member's have
searched for information on this disease, we have found none.  What can you
tell us and what can we expect?

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ANSWER:  This is an uncommon disease that affects men twice as often as women.
It usually begins with complaints of slowness of movement, imbalance and
falling, and impaired vision, and strikes in patients in the 60 to 70 year age
range.  They note difficulty in negotiating steps and curbs, and marked
problems in looking upward or down.  It is this problem with vertical gaze
that leads physicians to the diagnosis for it is the hallmark of the disease.
As the name indicates the disease is progressive, and leads to difficulty in
moving and turning, an expressionless face, slurred and forced speech
patterns.  Though there are no specific laboratory tests available that help
in making the diagnosis, the appearance of the patient, and the slow
progression of the clinical symptoms and signs leave little doubt of its
identity.  We know that it damages the nerves in the brain, but have no idea
of the cause of this degeneration.  The disease progresses steadily over a six
to eight year period, and mental changes of apathy and dementia may occur late
in the course of the affliction.  Trials of treatment have left much to be
desired although three classes of medication, dopaminergic, anticholinergic or
antiserotonic drugs have been reported to help some patients.  I am sorry I
don't have more hopeful information to give you.
ÿ
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The material contained here is "FOR INFORMATION ONLY" and should not replace 
the counsel and advice of your personal physician.  Promptly consulting your 
doctor is the best path to a quick and successful resolution of any medical 
problem.
