$Unique_ID{BRK01886}
$Pretitle{}
$Title{CHLORZOXAZONE AND ACETAMINOPHEN COMBINATION}
$Subject{Blanex (Edwards)
Chlorofon-F (Rugby)
Chlorzone Forte (Schein)
chlorzoxazone and acetaminophen (various manufacturers)
Flexaphen (Trimen)
Lobac (Seatrace)
Mus-Lax (Jones Medical)
Paracet Forte (A.D.I.)
Polyflex (Holloway)}
$Volume{}
$Log{}

Copyright (C) 1991 Publications International, Ltd.


CHLORZOXAZONE AND ACETAMINOPHEN COMBINATION
------------------------------------------------------------------------------

BRAND NAMES (Manufacturers):
     Blanex (Edwards)
     Chlorofon-F (Rugby)
     Chlorzone Forte (Schein)
     chlorzoxazone and acetaminophen (various manufacturers)
     Flexaphen (Trimen)
     Lobac (Seatrace)
     Mus-Lax (Jones Medical)
     Paracet Forte (A.D.I.)
     Polyflex (Holloway)
TYPE OF DRUG:
     Muscle relaxant and analgesic
INGREDIENTS:
     chlorzoxazone and acetaminophen
DOSAGE FORMS:
     Tablets (250 mg chlorzoxazone and 300 mg acetaminophen)
     Capsules (250 mg chlorzoxazone and 300 mg acetaminophen)
STORAGE:
     Chlorzoxazone and acetaminophen combination tablets and capsules should
       be stored at room temperature in a tightly closed container.

USES

     Chlorzoxazone and acetaminophen combination is used to relax muscles and
to relieve the pain of sprains, strains, and other muscle injuries.
Chlorzoxazone acts as a central nervous system (brain and spinal cord)
depressant, which blocks reflexes involved in producing and maintaining muscle
spasms.  It does not act directly on tense muscles.

TREATMENT

     This medication should be taken with a full glass of water.  In order to
avoid stomach irritation, you can also take this medication with food or milk
(unless your doctor directs you to do otherwise).
     If you miss a dose of this medication, take the missed dose as soon as
possible, unless it is within three hours of your next scheduled dose.  In
that case, do not take the missed dose at all; just return to your regular
dosing schedule.  Do not double the next dose.

SIDE EFFECTS

     Minor.

     Constipation, diarrhea, dizziness, drowsiness, fatigue, headache,
heartburn, light-headedness, nausea, nervousness, overstimulation, stomach
cramps, or vomiting.  These side effects should disappear as your body adjusts
to the medication.
     Chlorzoxazone can cause your urine to become orange or reddish-purple in
color.  This is a harmless effect that will disappear when you stop taking the
drug.
     If you are constipated, increase the amount of fiber in your diet (fresh
fruits and vegetables, salads, bran, and whole-grain breads) and drink more
water (unless your doctor directs you to do otherwise).
     If you feel dizzy or light-headed, sit or lie down for a while; get up
slowly from a sitting or lying position, and be careful on stairs.

     Major.

     Tell your doctor about any side effects that are persistent or
particularly bothersome.  IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about
bloody or black, tarry stools; difficulty in urinating; fever; rash; sore
throat; severe abdominal pain; unusual bleeding or bruising; unusual weakness;
or yellowing of the eyes or skin.

INTERACTIONS

     Chlorzoxazone and acetaminophen combination interacts with several other
types of medications:
     1. Concurrent use of chlorzoxazone with other central nervous system
depressants (such as alcohol, antihistamines, barbiturates, benzodiazepine
tranquilizers, pain medications, narcotics, phenothiazine tranquilizers, and
sleeping medications) or with tricyclic antidepressants can cause extreme
drowsiness.
     2. Alcohol, barbiturates, and anticonvulsants can increase the liver
toxicity of large doses of acetaminophen.
     3. Long-term use of large doses of acetaminophen can increase the effects
of oral anticoagulants (such as warfarin), which can lead to bleeding
complications.
     Before starting to take this medication, BE SURE TO TELL YOUR DOCTOR
about any medications you are currently taking, especially any of those listed
above.

WARNINGS

     * Tell your doctor about unusual or allergic reactions you have had to
any medications, especially to chlorzoxazone or to acetaminophen.
     * Tell your doctor if you now have or if you have ever had blood
disorders or heart, kidney, liver, or lung disease.
     * If this medication makes you dizzy or drowsy, do not take part in any
activity that requires alertness, such as driving a car or operating
potentially dangerous equipment.
     * This medication should not be taken as a substitute for rest, physical
therapy, or other measures recommended by your doctor to treat your condition.
     * Because this product contains acetaminophen, additional medications
that contain acetaminophen should not be taken without your doctor's approval.
Check the labels on over-the-counter (nonprescription) pain, sinus, allergy,
asthma, diet, cough, and cold products before you use them to see if they
contain acetaminophen.
     * Be sure to tell your doctor if you are pregnant.  Extensive studies
have not been conducted to determine whether chlorzoxazone and acetaminophen
combination can be used safely during pregnancy.  Since this drug may
interfere with fetal development, your doctor should decide if the benefits of
its use clearly outweigh the possible risks to the fetus.  Also, tell your
doctor if you are breast-feeding an infant.  Small amounts of acetaminophen
pass into breast milk.  It is not known whether chlorzoxazone passes into the
milk.

----------------

The material contained here is "FOR INFORMATION ONLY" and should not replace 
the counsel and advice of your personal physician.  Promptly consulting your 
doctor is the best path to a quick and successful resolution of any medical 
problem.
