$Unique_ID{BRK02092}
$Pretitle{}
$Title{PHENYLPROPANOLAMINE AND CHLORPHENIRAMINE COMBINATION}
$Subject{Allerest 12-Hour (Pharmacraft)
Condrin-LA (Hauck)
Conex D.A. (Forest)
Contac 12-Hour (Smith Kline Consumer)
Dehist (Forest)
Demazin (Schering)
Drize (Ascher)
Dura-Vent/A (Dura)
Genamin (Goldline)
Gencold (Goldline)
Histabid Duracaps (Glaxo)
Myminic (My-K Labs)
Noraminic (Vortech)
Oragest T.D. (Major)
Oraminic (Vortech)
Ornade (Smith Kline & French)
phenylpropanolamine HCl and chlorpheniramine maleate (Cord)
Resaid S.R. (Geneva Generics)
Rhinolar-Ex 12 (McGregor)
Ru-Tuss II (Boots)
Triaminic (Dorsey)
Triaminic-12 (Sandoz)
Trind (Mead Johnson Nutrition)
Triphenyl (Rugby)}
$Volume{}
$Log{}

Copyright (C) 1991 Publications International, Ltd.


PHENYLPROPANOLAMINE AND CHLORPHENIRAMINE COMBINATION
------------------------------------------------------------------------------

BRAND NAMES (Manufacturers):
     Allerest 12-Hour [*] (Pharmacraft)
     Condrin-LA (Hauck)
     Conex D.A. [*] (Forest)
     Contac 12-Hour [*] (Smith Kline Consumer)
     Dehist [*] (Forest)
     Demazin [*] (Schering)
     Drize (Ascher)
     Dura-Vent/A (Dura)
     Genamin [*] (Goldline)
     Gencold [*] (Goldline)
     Histabid Duracaps (Glaxo)
     Myminic [*] (My-K Labs)
     Noraminic [*] (Vortech)
     Oragest T.D. (Major)
     Oraminic (Vortech)
     Ornade (Smith Kline & French)
     phenylpropanolamine HCl and chlorpheniramine maleate (Cord)
     Resaid S.R. (Geneva Generics)
     Rhinolar-Ex 12 (McGregor)
     Ru-Tuss II (Boots)
     Triaminic [*] (Dorsey)
     Triaminic-12 [*] (Sandoz)
     Trind [*] (Mead Johnson Nutrition)
     Triphenyl (Rugby)
  *  Available over-the-counter (without a prescription)
TYPE OF DRUG:
     Adrenergic (decongestant) and antihistamine
INGREDIENTS:
     phenylpropanolamine and chlorpheniramine
DOSAGE FORMS:
     Oral tablets (25 mg or 37.5 mg phenylpropanolamine and 4 mg
       chlorpheniramine)
     Sustained-release tablets (25 mg phenylpropanolamine and 4 mg
       chlorpheniramine)
     Sustained-release capsules (75 mg phenylpropanolamine and 4 mg, 8 mg, 10
       mg, or 12 mg chlorpheniramine)
     Oral syrup (12.5 mg phenylpropanolamine and 2 mg chlorpheniramine per
       5-ml spoonful, with 5% or 7.5% alcohol)
STORAGE:
     Phenylpropanolamine and chlorpheniramine combination tablets, capsules,
       and oral syrup should be stored at room temperature (never frozen) in
       tightly closed containers.

USES

     This drug combination is used to relieve the symptoms of upper
respiratory tract infections, hay fever and other allergies, and sinusitis
(inflammation of the sinuses).
     Phenylpropanolamine belongs to a group of drugs known as adrenergic
agents (decongestants).  They act by constricting (narrowing) blood vessels in
the nasal passages, thereby reducing swelling and congestion.
     Chlorpheniramine belongs to a group of drugs known as antihistamines,
which block the action of histamine, a chemical released by the body during an
allergic reaction.  It is used to relieve or prevent symptoms of allergy.

TREATMENT

     In order to avoid stomach upset, you can take phenylpropanolamine and
chlorpheniramine combination with food or with a full glass of milk or water
(unless your doctor directs you to do otherwise).
     The oral syrup form of this medication should be measured carefully with
a specially designed 5-ml measuring spoon.  An ordinary kitchen teaspoon is
not accurate enough.
     The sustained-release tablets and capsules should be swallowed whole.
Breaking, chewing, or crushing these tablets or capsules destroys their
sustained-release activity and may increase the side effects.
     If you miss a dose of this medication, take the missed dose as soon as
possible, unless it is almost time for your next dose.  In that case, do not
take the missed dose at all; just return to your regular dosing schedule.  Do
not double the next dose.

SIDE EFFECTS

     Minor.

     Anxiety; blurred vision; constipation; diarrhea; dizziness; drowsiness;
dry mouth, nose, and throat; heartburn; insomnia; irritability; loss of
appetite; nasal congestion; nausea; restlessness; decreased sweating;
vomiting; or weakness.  These side effects should disappear as your body
adjusts to the medication.
     This medication can increase your sensitivity to sunlight.  Avoid
prolonged exposure to sunlight and sunlamps, wear protective clothing, and use
an effective sunscreen.
     If you are constipated, increase the amount of fiber in your diet (fresh
fruits and vegetables, salads, bran, and whole-grain breads), exercise, and
drink more water (unless your doctor directs you to do otherwise).
     Chew sugarless gum or suck on ice chips or a piece of hard candy to
reduce mouth dryness.
     If you feel dizzy or light-headed, sit or lie down for a while; get up
slowly from a sitting or reclining position, and be careful on stairs.
     In order to avoid difficulty in falling asleep, take the last dose of
this medication several hours before bedtime.

     Major.

     Tell your doctor about any side effects that are persistent or
particularly bothersome.  IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about
chest pain, convulsions, difficult or painful urination, difficulty in
breathing, fainting, hallucinations, headaches, loss of coordination,
confusion, mood changes, nosebleeds, palpitations, rash, severe abdominal
pain, sore throat, or unusual bleeding or bruising.

INTERACTIONS

     This drug interacts with several other types of drugs:
     1. Concurrent use of it with central nervous system depressants (such as
alcohol, barbiturates, benzodiazepine tranquilizers, muscle relaxants,
narcotics, pain medications, and phenothiazine tranquilizers) or with
tricyclic antidepressants can cause extreme drowsiness.
     2. Monoamine oxidase (MAO) inhibitors (isocarboxazid, pargyline,
phenelzine, tranylcypromine) and tricyclic antidepressants can increase the
side effects of this medication.  At least 14 days should separate the use of
this drug and the use of an MAO inhibitor.
     3. The side effects of the antihistamine part of this medication may be
increased by quinidine, procainamide, haloperidol, and phenothiazine
tranquilizers; and the side effects of the decongestant component may be
increased by digoxin or over-the-counter (nonprescription) diet, allergy,
asthma, cough, cold, or sinus preparations.
     4. The blood-pressure-lowering effects of guanethidine may be decreased
by this medication.
     BE SURE TO TELL YOUR DOCTOR about any medications you are currently
taking, especially any listed above.

WARNINGS

     * Tell your doctor about unusual or allergic reactions you have had to
any medications, especially to chlorpheniramine or other antihistamines (such
as azatadine, brompheniramine, carbinoxamine, clemastine, cyproheptadine,
dexchlorpheniramine, dimenhydrinate, diphenhydramine, diphenylpyraline,
doxylamine, hydroxyzine, promethazine, pyrilamine, trimeprazine,
tripelennamine, and triprolidine) or to phenylpropanolamine or other
adrenergic agents (such as albuterol, amphetamines, ephedrine, epinephrine,
isoproterenol, metaproterenol, norepinephrine, pseudoephedrine, and
terbutaline).
     * Tell your doctor if you now have or if you have ever had diabetes
mellitus, epilepsy, glaucoma, heart or blood vessel disease, hiatal hernia,
high blood pressure, myasthenia gravis, obstructed bladder or intestinal
tract, peptic ulcers, enlarged prostate gland, or thyroid disease.
     * Because this drug can reduce sweating and heat release from the body,
avoid excessive work or exercise in hot weather, and do not take hot baths,
showers, or saunas.
     * This medication can cause drowsiness.  Exercise caution when performing
tasks that require alertness, such as driving a car or operating potentially
dangerous machinery.
     * Be sure to tell your doctor if you are pregnant.  The effects of this
medication during pregnancy have not been thoroughly studied in humans.  Also,
tell your doctor if you are breast-feeding an infant.  Small amounts of this
medication pass into breast milk and may cause unusual excitement or
irritability in nursing infants.

----------------

The material contained here is "FOR INFORMATION ONLY" and should not replace 
the counsel and advice of your personal physician.  Promptly consulting your 
doctor is the best path to a quick and successful resolution of any medical 
problem.
