$Unique_ID{BRK02093}
$Pretitle{}
$Title{PHENYLPROPANOLAMINE AND GUAIFENESIN COMBINATION}
$Subject{BanexLA (Lu Chem)
Dura-Vent (Dura)
Entex L.A. (Norwich-Eaton)
Guipax (Vitarine)
Nolex LA (Carnrick)
Rymed-TR (Edwards)
Tega D & E (Ortega)}
$Volume{}
$Log{
Entex L.A.*0209301.scf}

Copyright (C) 1991 Publications International, Ltd.


PHENYLPROPANOLAMINE AND GUAIFENESIN COMBINATION
------------------------------------------------------------------------------

BRAND NAMES (Manufacturers):
     BanexLA (Lu Chem)
     Dura-Vent (Dura)
     Entex L.A. (Norwich-Eaton)
     Guipax (Vitarine)
     Nolex LA (Carnrick)
     Rymed-TR (Edwards)
     Tega D & E (Ortega)
TYPE OF DRUG:
     Adrenergic (decongestant) and expectorant
INGREDIENTS:
     phenylpropanolamine and guaifenesin
DOSAGE FORM:
     Sustained-release tablets (75 mg phenylpropanolamine and 400 mg or 600 mg
       guaifenesin)
STORAGE:
     Phenylpropanolamine and guaifenesin combination tablets and capsules
       should be stored at room temperature in tightly closed containers.

USES

     This drug combination is used to relieve the coughing and congestion
associated with colds, sinusitis (inflammation of the sinuses), sore throat,
bronchitis, and asthma.
     Phenylpropanolamine belongs to a group of drugs known as adrenergic
agents (decongestants).  They act by constricting (narrowing) blood vessels in
the nasal passages, thereby reducing swelling and congestion.
     Guaifenesin is an expectorant, a drug that loosens bronchial secretions.

TREATMENT

     In order to avoid stomach upset, you can take phenylpropanolamine and
guaifenesin combination with food or with a full glass of milk or water
(unless your doctor directs you to do otherwise).
     These sustained-release tablets should be swallowed whole.  Breaking,
chewing, or crushing them destroys their sustained-release activity and may
increase side effects.
     If you miss a dose of this medication, take the missed dose as soon as
possible, unless it is almost time for your next dose.  In that case, do not
take the missed dose at all; just return to your regular dosing schedule.  Do
not double the next dose.

SIDE EFFECTS

     Minor.

     Insomnia, nervousness, or restlessness.  These side effects should
disappear as your body adjusts to the medication.
     In order to help you avoid difficulty in falling asleep, take the last
dose of this medication several hours before bedtime.

     Major.

     Tell your doctor about any side effects that are persistent or
particularly bothersome.  IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about
fainting, headaches, nosebleeds, or palpitations.

INTERACTIONS

     Phenylpropanolamine and guaifenesin combination interacts with several
other types of medications:
     1. Monoamine oxidase (MAO) inhibitors (isocarboxazid, pargyline,
phenelzine, tranylcypromine) can increase the side effects of this medication.
At least 14 days should separate the use of this drug and the use of an MAO
inhibitor.
     2. The blood-pressure-lowering effects of guanethidine may be decreased
by this medication.
     3. The side effects of the decongestant component of this medication can
be increased by digoxin or by over-the-counter (nonprescription) allergy,
asthma, cough, cold, diet, or sinus preparations.
     BE SURE TO TELL YOUR DOCTOR about any medications you are currently
taking, especially any listed above.

WARNINGS

     * Tell your doctor about unusual or allergic reactions you have had to
any medications, especially to guaifenesin or phenylpropanolamine or to other
adrenergic agents (such as albuterol, amphetamines, ephedrine, epinephrine,
isoproterenol, metaproterenol, norepinephrine, pseudoephedrine, and
terbutaline).
     * Tell your doctor if you now have or if you have ever had diabetes
mellitus, glaucoma, heart or blood vessel disease, high blood pressure,
enlarged prostate, or thyroid disease.  While you are taking
phenylpropanolamine and guaifenesin combination, drink at least eight glasses
of water a day to help loosen bronchial secretions.
     * Be sure to tell your doctor if you are pregnant.  The effects of this
medication during pregnancy have not been thoroughly studied in humans.  Also,
tell your doctor if you are breast-feeding an infant.  Small amounts of this
medication may pass into breast milk.

----------------

The material contained here is "FOR INFORMATION ONLY" and should not replace 
the counsel and advice of your personal physician.  Promptly consulting your 
doctor is the best path to a quick and successful resolution of any medical 
problem.
