$Unique_ID{BRK02095}
$Pretitle{}
$Title{PHENYLPROPANOLAMINE, PHENYLEPHRINE, CHLORPHENIRAMINE, AND 
PHENYLTOLOXAMINE}
$Subject{Amaril D Spantab (Vortech)
Decongestabs (various manufacturers)
Histamic (Lexis)
Naldecon (Bristol)
Naldelate (various manufacturers)
Nalgest (Major)
New-Decongest (Goldline)
Tri-Phen-Chlor (Rugby)}
$Volume{}
$Log{
Naldecon*0209501.scf}

Copyright (C) 1991 Publications International, Ltd.


PHENYLPROPANOLAMINE, PHENYLEPHRINE, CHLORPHENIRAMINE, AND PHENYLTOLOXAMINE
COMBINATION
------------------------------------------------------------------------------

BRAND NAMES (Manufacturers):
     Amaril D Spantab (Vortech)
     Decongestabs (various manufacturers)
     Histamic (Lexis)
     Naldecon (Bristol)
     Naldelate (various manufacturers)
     Nalgest (Major)
     New-Decongest (Goldline)
     Tri-Phen-Chlor (Rugby)
TYPE OF DRUG:
     Adrenergic (decongestant) and antihistamine
INGREDIENTS:
     phenylpropanolamine, phenylephrine, chlorpheniramine, and
       phenyltoloxamine
DOSAGE FORMS:
     Sustained-release tablets (40 mg phenylpropanolamine, 10 mg
       phenylephrine, 5 mg chlorpheniramine, and 15 mg phenyltoloxamine)
     Sustained-release capsules (50 mg phenylpropanolamine, 25 mg
       phenylephrine, 12 mg chlorpheniramine, and 30 mg phenyltoloxamine)
     Oral syrup (20 mg phenylpropanolamine, 5 mg phenylephrine, 2.5 mg
       chlorpheniramine, and 7.5 mg phenyltoloxamine per 5-ml spoonful)
     Oral pediatric drops (5 mg phenylpropanolamine, 1.25 mg phenylephrine,
       0.5 mg chlorpheniramine, and 2 mg phenyltoloxamine per ml)
STORAGE:
     Store at room temperature in a tightly closed container.  This medication
       should never be frozen.

USES

     This drug combination is used to relieve symptoms of upper respiratory
tract infections, hay fever and other allergies, and sinusitis (inflammation
of the sinuses).
     Phenylpropanolamine and phenylephrine belong to a group of drugs known as
adrenergic agents (decongestants).  They act by constricting (narrowing) blood
vessels in the nasal passages, thereby reducing swelling and congestion.
     Chlorpheniramine and phenyltoloxamine belong to a group of drugs known as
antihistamines, which block the actions of histamine, a chemical released by
the body during an allergic reaction.  They are, therefore, used to relieve or
prevent the symptoms of allergy.

TREATMENT

     In order to avoid stomach upset, you can take phenylpropanolamine,
phenylephrine, chlorpheniramine, and phenyltoloxamine combination with food or
with a full glass of milk or water (unless your doctor directs you to do
otherwise).
     The oral pediatric drops should be measured carefully with the dropper
provided.
     The oral syrup form of this medication should be measured carefully with
a specially designed 5-ml measuring spoon.  An ordinary kitchen teaspoon is
not accurate enough for measuring your dosage of this medication.
     The sustained-release tablets and capsules should be swallowed whole.
Breaking, chewing, or crushing them destroys their sustained-release activity
and may increase the side effects.
     If you miss a dose, take it as soon as possible, unless it is almost time
for your next dose.  In that case, do not take the missed dose at all; just
return to your regular dosing schedule.  Do not double the next dose.

SIDE EFFECTS

     Minor.

     Anxiety; blurred vision; constipation; diarrhea; dizziness; drowsiness;
dry mouth, nose, and throat; heartburn; insomnia; irritability; loss of
appetite; nasal congestion; reduced sweating; restlessness; vomiting; or
weakness.  These side effects should disappear as your body adjusts to the
medication.
     This medication can increase your sensitivity to sunlight.  Avoid
prolonged exposure to sunlight and sunlamps, wear protective clothing, and use
an effective sunscreen.
     If you are constipated, increase the amount of fiber in your diet (fresh
fruits and vegetables, salads, bran, and whole-grain breads), exercise, and
drink more water (unless your doctor directs you to do otherwise).
     If you experience dry mouth or throat, you should try chewing sugarless
gum or sucking on ice chips or a piece of hard candy to reduce mouth dryness.
     If you feel dizzy or light-headed, sit or lie down for a while; get up
slowly from a sitting or reclining position, and be careful on stairs.
     In order to avoid difficulty in falling asleep, take the last dose of
this medication several hours before bedtime.

     Major.

     Tell your doctor about any side effects that are persistent or
particularly bothersome.  IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about
chest pain, confusion, convulsions, difficult or painful urination, difficulty
in breathing, fainting, hallucinations, headaches, loss of coordination, mood
changes, nosebleeds, palpitations, rash, severe abdominal pain, sore throat,
or unusual bleeding or bruising.

INTERACTIONS

     This medication interacts with several other types of drugs:
     1. Concurrent use of this medication with central nervous system
depressants (such as alcohol, barbiturates, benzodiazepine tranquilizers,
muscle relaxants, narcotics, pain medications, and phenothiazine
tranquilizers) or with tricyclic antidepressants can cause extreme drowsiness.
     2. Monoamine oxidase (MAO) inhibitors (isocarboxazid, pargyline,
phenelzine, tranylcypromine) and tricyclic antidepressants can increase the
side effects of this medication.  At least 14 days should separate the use of
this drug and the use of an MAO inhibitor.
     3. The side effects of the antihistamine part of this medication may be
increased by quinidine, procainamide, haloperidol, and phenothiazine
tranquilizers; and the side effects of the decongestant component may be
increased by digoxin or by over-the-counter (nonprescription) allergy, asthma,
cough, cold, diet, or sinus preparations.
     4. The blood-pressure-lowering effects of guanethidine may be decreased
by this medication.
     BE SURE TO TELL YOUR DOCTOR about any medications you are currently
taking, especially any of the medications that are listed above.

WARNINGS

     * Tell your doctor about unusual or allergic reactions you have had to
any medications, especially to chlorpheniramine, phenyltoloxamine, or any
other antihistamine (such as azatadine, brompheniramine, carbinoxamine,
clemastine, cyproheptadine, dexchlorpheniramine, dimenhydrinate,
diphenhydramine, diphenylpyraline, doxylamine, hydroxyzine, promethazine,
pyrilamine, trimeprazine, tripelennamine, and triprolidine), or to
phenylpropanolamine, phenylephrine, or any other adrenergic agent (such as
albuterol, amphetamines, ephedrine, epinephrine, isoproterenol,
metaproterenol, norepinephrine, pseudoephedrine, and terbutaline).
     * Tell your doctor if you now have or if you have ever had diabetes
mellitus, epilepsy, glaucoma, heart or blood vessel disease, hiatal hernia,
high blood pressure, myasthenia gravis, obstructed bladder or intestinal
tract, peptic ulcers, enlarged prostate gland, or thyroid disease.
     * Because this drug can reduce sweating and heat release from the body,
you should avoid excessive work or exercise in hot weather and you should not
take hot baths, showers, and saunas while taking this medication.
     * This medication can cause drowsiness.  Your ability to perform tasks
that require alertness, such as driving a car or operating potentially
dangerous machinery, may be decreased.  Appropriate caution should, therefore,
be taken.
     * Be sure to tell your doctor if you are pregnant.  The effects of this
medication during pregnancy have not been thoroughly studied in humans.  Also,
tell your doctor if you are breast-feeding an infant.  Small amounts of this
medication pass into breast milk and may cause unusual excitement or
irritability in nursing infants.

----------------

The material contained here is "FOR INFORMATION ONLY" and should not replace 
the counsel and advice of your personal physician.  Promptly consulting your 
doctor is the best path to a quick and successful resolution of any medical 
problem.
