$Unique_ID{BRK01872}
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$Title{CHENODIOL}
$Subject{Chenix (Reid-Rowell)}
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Copyright (C) 1991 Publications International, Ltd.


CHENODIOL
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BRAND NAME (Manufacturer):
     Chenix (Reid-Rowell)
TYPE OF DRUG:
     Gallstone dissolver
INGREDIENT:
     chenodiol
DOSAGE FORM:
     Tablets (250 mg)
STORAGE:
     Chenodiol tablets should be stored at room temperature in a tightly
       closed container.

USES

     This medication is used to dissolve gallstones in individuals who cannot
tolerate surgery.  Chenodiol is a naturally occurring bile acid that blocks
the body's production of cholesterol.  This action leads to gradual
dissolution of cholesterol gallstones.  It has no effect on calcified
gallstones.

TREATMENT

     In order to obtain the maximum benefit from this medication, you should
take it with food or milk.  It is important to continue taking this medication
for the entire time prescribed by your doctor (usually six months to two
years), even if your symptoms disappear.  If you stop using this drug too
soon, your symptoms could recur (the gallstones may not have completely
dissolved).
     If you miss a dose of this medication, take the missed dose as soon as
possible, unless it is almost time for the next dose.  In that case, do not
take the missed dose at all; just return to your regular dosing schedule.  Do
not double the next dose.

SIDE EFFECTS

     Minor.

     Constipation, diarrhea, gas, heartburn, loss of appetite, nausea, stomach
cramps, or vomiting.  These side effects should disappear as your body adjusts
to the medication.
     To relieve constipation, increase the amount of fiber in your diet (fresh
fruits and vegetables, salads, bran, and whole-grain breads), exercise, and
drink more water (unless your doctor directs you to do otherwise).
     If diarrhea continues to be a problem, contact your doctor.
Antidiarrheal medications may be effective for short periods, or your doctor
may want to decrease your dose of chenodiol.

     Major.

     Tell your doctor about any side effects that are persistent or
particularly bothersome.  IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about
yellowing of the eyes or skin.

INTERACTIONS

     Chenodiol interacts with other types of medications:
     1. Cholestyramine, colestipol, and aluminum-containing antacids can
decrease the absorption of chenodiol from the gastrointestinal tract.
     2. Estrogen-containing drugs, oral contraceptives (birth control pills),
probucol, and clofibrate can counteract the effectiveness of chenodiol.
     Before you start to take this medication, BE SURE TO TELL YOUR DOCTOR
about any medications you are currently taking, especially any of those listed
above.

WARNINGS

     * Tell your doctor about any unusual or allergic reactions you have had
to medications, especially to chenodiol.
     * Tell your doctor if you now have or if you have ever had biliary tract
disease, blood vessel disease, colon cancer, inflammatory bowel disease, liver
disease, or pancreatitis.
     * Body weight and diet influence the formation and dissolution of
gallstones.  A high-fiber, low-fat diet and weight reduction are recommended
to increase the effectiveness of chenodiol.
     * Be sure to tell your doctor if you are pregnant.  Although extensive
studies in humans have not been conducted, this medication has caused birth
defects in the offspring of animals that received large doses of it during
pregnancy.  Also, tell your doctor if you are breast-feeding.  It is not known
whether chenodiol passes into breast milk.

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The material contained here is "FOR INFORMATION ONLY" and should not replace 
the counsel and advice of your personal physician.  Promptly consulting your 
doctor is the best path to a quick and successful resolution of any medical 
problem.
